Contract research

Chemical production of nucleoside and nucleotide analogs is difficult. Plenty reactive groups require multiple protection, deprotection and purification steps throughout the synthesis process. This gives rise to a host of production problems, including high purification effort, low yields, excessive waste and the need for large production lines.

At BioNukleo, we specialize in harnessing the power of enzymes - nature's catalysts - to provide innovative and sustainable solutions for the synthesis of modified nucleosides, nucleotides and related fine chemicals. Together we will find a solution to create your desired fine-chemical or improve and facilitate your existing process.

Why choose BioNukleo?

Expertise and Experience: Our team of skilled scientists and researchers brings extensive expertise in biocatalysis, biotechnology, protein biochemistry, protein production, and nucleoside chemistry. We have the know-how and experience to meet the unique needs and challenges of customers in this specialized field.


Innovative and Sustainable Solutions: Biocatalysis allows for reactions with high selectivity and specificity, mild reaction conditions, and reduced environmental impact, which align with the growing demand for sustainable chemical manufacturing. With the help of our extensive enzyme library we can replace critical chemical synthesis steps and reduce the amount of time and factory space needed, improve yields, or reduce the purification effort - and thereby create simpler, greener, and cheaper processes. Our solutions can help customers achieve their sustainability goals while maintaining high-quality product outcomes.


Customized Approach: We understand that every synthesis challenge is unique. That's why we offer tailored solutions that are customized to meet the specific needs of our partners and clients. From research collaborations to product development partnerships, we work closely with our customers to deliver solutions that are designed to address their specific requirements. As a small and young team of experts, flexibility and problem-solving ability are two of our strongest points.


Excellent Customer Support: At BioNukleo, we take pride in providing excellent customer support. We are always available and willing to assist our customers with technical expertise, process optimization, and troubleshooting. We value long-term partnerships and strive to ensure the success of our customers in every aspect of their projects.


Collaborative Approach: BioNukleo actively collaborates with industry partners, academic institutions, and other stakeholders to promote the use of biocatalysis as a sustainable and efficient solution for fine chemical synthesis and other areas of science. 


Quality and Compliance: At BioNukleo, we are commited to maintaining rigorous quality control measures and adhering to regulatory compliance as needed. Safety and product quality are our utmost priority.

Contact us today!

We offer complete development of a biocatalytic manufacturing process for nucleic acid derivatives. We cover all steps of process development starting from initial small batch testing (enzyme screening and route scouting) via process validation and optimization to upscaling strategies for industrial production - and deliver professional process descriptions tailored to your specific needs. Do you need a special nucleoside or nucleotide analog? We develop a process for you. We are also open to collaborations. Please contact us via e-mail, phone or our contact form.

Production processes that BioNukleo has developed or is currently developing:

  • Cladribine
  • Cytarabine
  • Clofarabine
  • Ribavirin