Establishing an enzymatic reaction procedure for modified nucleic acid derivatives can be difficult. The enzymatic activity of our enzymes will vary greatly depending on the steric and chemical properties of different compounds. Selection of the most favourable enzyme (combination) and identification of the best reaction conditions is highly recommended.

The selection of the correct enzyme depends on several factors:

• enzyme activity towards specific modifications
• single step or multi-step reaction
• solubility concerns
• purification concerns
• if multi-step: enzyme compatibility and reaction conditions

By combining our expertise with semi-automated screening techniques, we can reliably identify which enzyme(s) out of our portfolio best suits your needs and at what conditions the desired product formation is most optimal. 

Please contact us for further information.