Nucleoside analogues are extensively applied as antiviral, antimicrobial or anticancer agents as they act as reverse transcriptase inhibitors or interfere with DNA or RNA synthesis.

Due to the complexity and drawbacks of chemical synthesis routes, the biotechnologic and pharmaceutical industry are constantly searching for enzymatic or chemo-enzymatic synthesis routes.

BioNukleo has established libraries of enzymes involved in the nucleoside and nucleotide metabolic pathway. The enzymes were carefully selected to meet our customer's requirements. They either show a broad or very specific substrate spectrum and they are active over a wide range of temperatures and pH values.

* Image taken from the RCSB PDB ( of PDB ID 1B8N