Chemical production of nucleoside and nucleotide analogs is difficult. Plenty reactive groups require multiple protection, deprotection and purification steps throughout the synthesis process. This gives rise to a host of production problems, including high purification effort, low yields, excessive waste and the need for large production lines.


With the help of our extensive enzyme library we can replace critical chemical synthesis steps and create simpler, better and greener processes.


We offer complete development of a biocatalytic manufacturing process for nucleic acid derivatives. By including enzymatic steps in the process, BioNukleo provides an optimal synthesis solution that cuts costs, reduces the amount of time and factory space needed, and improves the ecological footprint.


We cover all steps of process development starting from initial small batch testing (enzyme screening and route scouting) via process validation and optimization to upscaling strategies for industrial production - and deliver professional process descriptions tailored to your specific need.


Production processes that BioNukleo has developed or is currently developing:

  • Cladribine
  • Cytarabine
  • Clofarabine
  • Ribavirin

Do you need a special nucleoside or nucleotide analog? We develop a process for you. We are also open to collaborations. Please contact us via e-mail, phone or our contact form.